Compliance to guidelines in reporting animal research: A case examine
Case: An author submitted a paper to an international journal to report a pre-clinical trial. The investigate tested the efficacy and safety of using a fresh medical device on an animal model. However, the journal editor wrote to the author asking whether all necessary regulations had been followed and requested him to submit the ARRIVE checklist. The author was not sure of what regulations he was expected to go after and had not heard of the ARRIVE checklist. He therefore approached Editage Insights for guidance.
Activity: Our experts explained to the author that the ARRIVE(Animal Research: Reporting of In Vivo Experiments) guidelines are international guidelines for reporting studies involving animals, and the ARRIVE checklist is a form that should be packed and submitted along with the manuscript as a supplementary document for any examine on animals. We guided the author on the details to be included in this form.
However, while packing the form, one area of concern came to light. The investigate did not have the approval of a national or an international ethical committee. The author explained that this was because the author’s home country did not have any ethical committee for experiments involving animals. Our experts asked him to explain this in the checklist and also to write a separate email to the editor explaining this problem.
The editor was pleased with the details that the author provided in the checklist, and agreed to accept the approval of the author’s institutional review board in the absence of a national ethical committee. The author had this approval, but it was in the author’s native language. However, the editor accepted this, telling that this could be translated at the journal end.
Summary: Journals receive submissions from different research groups based in different countries. However, guidelines governing the use and care of animals in scientific research vary across nations and institutions. Therefore, most journals encourage the use of the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines to standardize and improve the reporting of research using animals. The guidelines include a checklist of 20 items “describing the minimum information that all scientific publications reporting research using animals should include,” such as the hook-up and number of animals in the investigate, their husbandry and care, details of their health status, the experimental procedures used, including dosage of drugs, anesthesia, method of euthanasia, etc.
Most governments and the scientific community in general aim to have a humane treatment towards animals used in research, and to that effect attempt to control the number of times individual animals may be used; the total number of animals used; the conditions in which they are housed, and the degree of ache that may be inflicted. The ARRIVE guidelines are a step forward in this direction. It is therefore very recommended that authors and journals go after these guidelines.